Compared with model group, positive group T - AOC, SOD activity and MDA content in mice there was no significant difference; Plant extracts compound can make the body in model mice T - AOC and increase SOD activity, MDA content decreased, significantly improve the state of oxidative stress in mice, including plant extracts compound high dose group is better than that of low dose group. Plant best green coffee bean extract extracts compound T AOC, SOD content in high dose group were significantly increased by 50.2% in the model group (P < 0.05), 35.2% (P < 0.01), MDA content was reduced by 20.6% (P < 0.01). Therefore, plant extracts compound help diabetic mice to remove free radicals and dead cells, strengthen the body's immune system.
Plant extracts compound on diabetes mice liver oxidative stress indicators 4 weeks after the treatment, the influence of each group in mice liver antioxidant index compared with normal control group, model group T AOC and SOD vitality in mice significantly reduced, respectively, 38.7% lower than normal control group (P < 0.01) and 27.1% (P < 0.01). MDA content significantly increased in saw palmetto extract model mice (P < 0.01), compared with normal control group increased by 78.1%. The results show that the antioxidant ability in model mice is damaged, the body ability is abate, scavenging free radicals and necrotic cells produce the harmful ingredients of increase.
Plant extracts the main effective components in the compound of pumpkin polysaccharide, yam polysaccharide and puerarin, content, respectively (0.93 + 0.04), (1.01-0.06), (0.28-0.01) g / 100 g (in raw material dry weight). Intervention after 4 weeks, compared with model group, plant extracts compound quality, the content of hepatic glycogen of mice body increased significantly, diet drink, fasting fenugreek saponins blood glucose concentration, amount of GSP concentration and the available relative content significantly decreased, insulin sensitivity, and the effect of high dose is better than the low dose. Plant extracts compound group compared with model group total antioxidant capacity and superoxide dismutase (sod) activity increased significantly, propylene.
Plant extracts compound available on diabetes mice relative content in the experimental period, the influence of model group mice available relative content is 2.67 times that of the normal control group, model group mice diabetes severe symptoms and high blood glucose levels, glucose metabolism in mice was badly damaged, high serum levels of available changes of red blood cells of lutein eye complex affinity for oxygen, make the tissue and cell hypoxia, easy to cause disease of heart head blood-vessel of mice and concurrency symptoms. Available relative content in mice serum positive group compared with model group significantly reduced by 30.9% (P < 0.01), indicating that acarbose in nearly a month of experimental period can be effectively by controlling the lower blood sugar levels in mice, mice available relative content played a role. Plant extracts compound low and high dose group mice available relative content, down 12.2% than the model group (P < 0.05) and 37.8% (P < 0.01). The results showed that the plant extracts compound on the irreversible mice induced by alloxan diabetes have auxiliary therapy effect, can relieve symptoms of diabetes in mice, the relative contents of blood sugar concentration and available is reduced, and the effect of high dose is better than the low dose.