Plant extracts compound impact on diabetes mice insulin tolerance in mice after injection of insulin, 0 ~ 60 minutes, decreasing blood sugar levels, groups of mice 60 min to a minimum. Then 60 ~ 120 min, elevated blood sugar concentration groups of mice, the analysis of 120 min and 0 min blood sugar concentration ratio, normal control group, model group, positive group, plant gynostemma pentaphyllum leaf extract extracts, compound low and high dose group were 79.0%, 88.8%, 85.3%, 83.7%, 75.1%. The results show that the model group mice to insulin sensitivity is greatly reduced, the blood sugar to rise after the lowest rate, high insulin resistance. Acarbose and low doses of plant extracts compound can improve insulin sensitivity in mice, the blood sugar recovery rate with the model group had no significant difference (P > 0.05). High dose compound plant extract can significantly enhance the insulin sensitivity in mice (P < 0.05).
Plant extracts compound effect on diabetes mice liver glycogen content in model group mice hepatic glycogen in normal control group was significantly higher than that in mice, 53.7% less than normal control group (P < 0.01). Positive group and plant extracts compound content of hepatic glycogen of low dose group compared with model group there was no significant difference (P > 0.05), plant jujube seed powder extracts compound liver glycogen content in high dose group compared with model group increased by 32.5% (P < 0.05). Results show that the alloxan induced diabetic mice, mice liver damaged liver glycogen synthesis ability, plant extracts compound high dose can significantly improve the ability of mice liver glycogen synthesis, but still not back to normal levels, in the short term can not meet the degree of cure.
Plant extracts compound GSP concentration on diabetes mice groups of mice serum concentration of GSP, the influence of the normal control group mice GSP concentration is 1.30 tendency for L, GSP concentration tendency for 1.87 L model lutein and zeaxanthin supplements group mice, significantly increased by 43.8% compared with normal control group (P < 0.01), indicating that model group mice blood glucose concentration is very high, nearly two weeks.
Plant extracts compound the effects on the diabetic mice fasting glucose concentration in the normal control group starting average blood glucose concentration is 6.7 tendency for L, the rest of the four groups of mice after the mold was made in alloxan, blood sugar levels in mice average tendency for 22.1 L. Compared with normal control group, model group overall showed a trend of ghana seed extract increased blood sugar levels. Compared with model group, positive, plant extracts, compound low dose group and high dose group overall showed a trend of gradually reduce blood sugar levels. 4 weeks at the end of the experiment, the normal control group mice blood sugar levels remain at (6.9 + 0.2) tendency/L; Reached the highest concentration of blood glucose in model mice tendency for 24.8 L, 12.2% increase from the early experiments. Positive group and plant extracts compound high dose group of the most significant effect of lower blood glucose in mice, the early experiments respectively reduced by 23.2% (P < 0.01) and 18.4% (P < 0.05). The results show that the model of alloxan diabetic mice without treatment diabetes symptoms aggravate, blood sugar levels continue to rise.